Endocrine Abstracts

Reproduction is controlled by hypothalamic GnRH acting on the pituitary gonadotrope to regulate LH and FSH. Activin, follistatin, and gonadal steroids modulate the gonadotrope as well. We have created immortalized pituitary gonadotropes and a series of their progenitor cells that represent sequential stages of differentiation. These have allowed the identification of transcription factors responsible for specific developmental transitions such as the initiation of LH and FSH g...